Jose Mourinho had already declared his intention to ring the changes for Manchester United’s Europa League campaign even before defeat to Manchester City on Saturday.
But after the derby disaster, there is more at stake for the players who will be drafted in at Feyenoord on Thursday night.
Had United beaten City at Old Trafford, Mourinho’s first choice XI would have been given the night off in Holland and then brought back for the trip to Watford at Vicarage Road on Sunday.
Instead, for the first time since the Portuguese coach arrived to replace Louis van Gaal, there are places up for grabs.
Mourinho is working with a first-team squad of 23 outfield players – not including Bastian Schweinsteiger – and three goalkeepers.
And if he wants to make 11 changes, he could – and with players left over.
The United manager has made no secret of his disdain for the Europa League in the past, but the game in De Kuip has taken on greater importance for his squad after what happened on Saturday.
Sergio Romero, who is yet to play this season, should come in for David De Gea, while Mourinho could pick a completely different back four of Matteo Darmian, Marcos Rojo, Chris Smalling and Phil Jones.
Rojo is likely to replace Luke Shaw at left-back after the 21-year-old picked up a minor hamstring injury during the defeat to City.
It represents an opportunity for Smalling, in particular, to win back his place.
The England centre-back was a regular under Van Gaal last season but has been keep out by the impressive form of Eric Bailly and Daley Blind.
In midfield, Michael Carrick and Morgan Schneiderlin are available despite not starting competitive game under Mourinho. Carrick is yet to be included in a match day squad this season.
Herrera, who came on as a half-time substitute against City, could also start for the first time since the opening day win over Bournemouth.
Mourinho has already revealed Marcus Rashford will start for the first time this season, possibly instead of Zlatan Ibrahimovic.
Memphis Depay and Ashley Young could fill the wide roles, although Anthony Martial only played for nine minutes on Saturday and could be recalled.
Jesse Lingard and Henrikh Mkhitaryan, who were both withdrawn at half-time during the derby, are likely to have to settle for places on the bench.